Chembiochem. 2010 Feb 15;11(3):396-410.

Chemical synthesis and biological screening of 2-aminoimidazole-based bacterial and fungal antibiofilm agents.
Rogers SA, Bero JD, Melander C.

Chemistry, North Carolina State University, 2620 Yarborough Drive, Raleigh, NC 27695-8204, USA.

Abstract
A collection of 2-aminoimidazole/triazole amides has been synthesized and screened for antibiofilm activity. This class of small molecules was found to modulate the biofilm activity of Pseudomonas aeruginosa, a multidrug-resistant strain of Acinetobacter baumannii (MDRAB), a methicillin-resistant Staphylococcus aureus strain (MRSA), Escherichia coli, Rhodospirillum salexigens, Staphylococcus epidermidis, Vibrio vulnificus, and vancomycin-resistant Enterococcus faecium as well as the yeast Candida albicans and Cryptococcus neoformans. Furthermore, lead compounds were found to not lyse red blood cells at active concentrations.

PMID: 20049758 [PubMed - in process]