More specific bands in the IgG western blot in sera
from Scottish patients with,suspected Lyme borreliosis.

J Clin Pathol. 2010 Jun 30; [Epub ahead of print]

More specific bands in the IgG western blot in sera from Scottish
patients with suspected Lyme borreliosis.

Evans R, Mavin S, McDonagh S, Chatterton JM, Milner R, Ho-Yen DO.

Microbiology Department, Raigmore Hospital, Inverness, UK.

Aims
To identify further Western blot bands that may be specific in
the diagnosis of Lyme borreliosis.

Methods
The Borrelia burgdorferi antibody profiles of 270 western blot
positive patients and 241 western blot negative patients from
2008 were examined.

Results
27 different non-specific bands were detected in both groups. Six
of 27 (22%) of the non-specific bands were detected significantly
more in the western blot positive patients compared to the
western blot negative patients (20 kDa, p<0.0001; 28 kDa,
p<0.002; 36 kDa, p<0.002; 37 kDa, p<0.007; 48 kDa, p<0.023; 56
kDa, p<0.028; two-tailed F test).

Conclusion
Results suggest that the 20, 28 and 48 kDa bands should be
regarded as specific.

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PMID: 20595179 [PubMed - as supplied by publisher]